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Finall Calli, I disagree with your last paragraph. Under current patent law this drug should not have been licensed. Nexium is not a different delivery mechanism. It is merely a purification of the same drug. AstraZeneca effectively patented a 50% pure drug, then 10 years later patented a 100% pure drug. That is illegal. It should never have been allowed. Further, if you look at the cited articles, the differences between the two are so small as to be laughable, and are easily explained by the fact they were effectively delivering twice the omeprazole dose with the nexium group. This was a highly unethical maneuver.