Glucocorticoid and mineralocorticoid effects of steroids

"Axis Recovery"

  • Slow reduction in dose over extended period of time
  • change dose rate every 3-4 weeks, change to EOD for first reduction
  • No ACTH (maintains negative feedback on hypothalamus)
  • Remember extra pred. for "stress"
  • Daily replacement therapy
    • Prednisone or prednisolone preferred
    • 1 mg/kg of hydrocortisone activity each day (dog)
    • - mg/kg prednisone, prednisolone "normal" secretion rate not known for other species
  • "Stressful" Situations
    • additional prednisone or prednisolone
Anti-inflammatory and Anti-immunologic Therapy Steroids are potent drugs for interrupting events triggered at the cell membrane (prostaglandins, phospholipase, etc.), and cell mediated immunity (antigen recognition, cell migration, etc.)

Glucocorticoid and mineralocorticoid effects of steroids

glucocorticoid and mineralocorticoid effects of steroids

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