The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system. 
A dermatologist diagnoses the condition by focusing on the key symptoms of dermatographism and questioning the patient’s history. The dermatologist uses a wooden tongue depressor and runs it down the patient’s back using mild to moderate force to see if a welt develops within a few minutes. The back is normally used rather than the arms or any other body part because it is more sensitive. The back area of the body tends to be more protected from day-to-day pressure exposure and environmental influences. A dermatographometer or dermographometer, which is simply a spring-loaded stylus can be used in the diagnosis. This instrument applies graded and reproducible pressure to the skin and is mainly used in clinical studies or to diagnose if the dermatographism is mild, moderate, or severe.