Mechanism of non steroid hormones

Most modern steroid enemas are foam based - as the likelihood of someone with colitis being able to retain a water based enema is quite low. These act topically applying the steroid directly to the colon - with only small amounts being absorbed into the bloodstream. This makes side effects less likely. The downside is that they can only reach the descending colon and rectum - so for those with extensive colitis oral steroids may be needed. A combination of Entocort and steroid enemas can provide topical treatment to the majority of the colon - again minimizing side effects. As the two main steroid enemas differ quite greatly I will cover them separately.

Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care 2014 (4th edition). Cambridge University Press. pp 141–53.

E-Learning for healthcare. E-Pain module: Non-steroidal Anti-inflammatory Drugs Available at http://-/LearningContent/Launch/389642 (last accessed 10 September 2016).

Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. Available at http:///formulary/bnf/current/10-musculoskeletal-and-joint-diseases/101-drugs-used-in-rheumatic-diseases-and-gout/1011-non-steroidal-anti-inflammatory-drugs (last accessed 10 September 2016).

Laidlaw T, Israel E. Aspirin-exacerbated respiratory disease. In: UpToDate, Bochner B (Ed). Available at URL: http:///contents/aspirin-exacerbated-respiratory-disease (last accessed 10 September 2016).

Mechanism of non steroid hormones

mechanism of non steroid hormones


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