In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75 mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450 mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia , unipolar and bipolar depression . Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100 mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected. [ 2 ]
Overdosing or abuse of this drug can lead to health complications such as oily skin, acne, exacerbation of male pattern baldness, growth of body/facial hair, deepening of the voice, and menstrual irregularities. The use of Mesterolone is not recommended to patients with carcinoma of the prostate or those who are undergoing androgen therapy of any kind, including the use of Proviron. In case a dose of this drug has been missed and it is almost time for the next dose, the first dose should be ignored and the next dose should be taken at the designated time. Under no circumstances, two doses of the drug should be taken together for the dose that was missed. Medical advice should be sought without any delay and use of Proviron should be stopped immediately if side effects such as pain in liver area, headache, loss of appetite, depression, unexplained weight loss, aggression, symptoms of an enlarged prostate (change in urination), acne, or hirsutism are experienced.