Following oral administration, dydrogesterone is rapidly metabolized to DHD. The levels of the main active metabolite DHD peak about hours postdose. The plasma levels of DHD are substantially higher as compared to the parent drug. The AUC and C max ratios of DHD to dydrogesterone are in the order of 40 and 25, respectively. Mean terminal half lives of dydrogesterone and DHD vary between 5 to 7 and 14 to 17 hours, respectively. A common feature of all metabolites characterised is the retention of the 4,6 diene-3-one configuration of the parent compound and the absence of 17α-hydroxylation. This explains the lack of estrogenic and androgenic effects of dydrogesterone.
An ancillary drug, for our purposes, can be defined as any drug that can be taken to off-set, the side effects sometimes associated with the use of anabolic steroids, or, to increase the desired effects of anabolic steroids. Didn't think the last part was coming, huh? Its true, specific non-anabolic drugs work very well with anabolic steroids and we are not just talking obvious drugs such as insulin and growth hormone (although we will have future discussions and guidance on both). Side effect prevention purposes range from various angles. As we've said before the main ones are your skin, your hair, your sex drive (and also those lovely raisin nuts juice causes you to have as testicles) and your degree of water retention. A good portion of these side effects stem from the relationship of estrogen and progesterone with respect to the male body. Some of the effects are caused by the sheer effect of the androgens alone. We will be able to greatly minimize side effects with proper ancillary drug usage, but there is no guarantee that we will eliminate it. The effectiveness of these drugs has everything to do with your diligence in using them correctly, and, your genetics.