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Salvia divinorum is a dissociative that is sometimes classified as an atypical psychedelic . The active molecule in the plant, salvinorin A , is a kappa opioid receptor agonist, working on a part of the brain that deals with pain. Activation of this receptor is also linked to the dysphoria sometimes experienced by users of opioids either therapeutically or recreationally. An unusual feature of S. divinorum is its high potency (dosage is in the microgram range) and extremely disorienting effects, which often include "entity contact", complete loss of reality-perception and user's experiencing their consciousness as being housed in different objects . a pane of glass or a pencil. Additionally, muscimol , the active constituent of Amanita muscaria , may be regarded as a psychedelic, dissociative or deliriant .

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