Phytoecdysteroids in plants

When purchasing spinach, look for leaves that have a vibrant, deep green color. Avoid any leaves that already look wilted or have wet, brown spots. Spinach is known to attract and hold bacteria somewhat easily, so wash it well before using it. It’s also best to buy organic spinach whenever possible, because conventionally grown spinach is one of the most pesticide-sprayed vegetable crops there is. According to The Environmental Working Group, most spinach contains multiple pesticides, some reports even showing it often has more contaminants than 320 other commonly eaten foods. ( 12 )

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Topping our who's who list of post-workout foods is chocolate milk , but not just any old chocolate milk, we're talking about the pre-formulated, protein-fortified, low-fat, great-tasting kind like Rockin' Refuel (also available in strawberry and vanilla, for the chocolate-averse gym rats). With 48 grams of carbs and 20 grams of whey protein, Rockin’ Refuel delivers the perfect ratio of carbs to protein, along with electrolytes and some other essential vitamins and minerals. Although making your own recovery drink is preferred by some guys, the convenience of having an all-in-one sports recovery drink handy after your workout simply can't be beat.

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone , which is secreted from the prothoracic glands . Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids . Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster , an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Recent findings in Chris Q. Doe lab have found a novel role of this hormone in regulating temporal gene transitions within neural stem cells. [1] Ecdysone and other ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps , yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties. [2] A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids.

8. Gorelick-Feldman J et al. Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells. Steroids. 2010 Oct;75(10):632-7. doi: /. Epub 2010 Apr 2.
9. Seidlova-Wuttke D1, Ehrhardt C, Wuttke W. Metabolic effects of 20-OH-ecdysone in ovariectomized rats. J Steroid Biochem Mol Biol. 2010 Apr;119(3-5):121-6. doi: /. Epub 2010 Jan 25.
10. Witard OC et al. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of wheyprotein at rest and after resistance exercise. Am J Clin Nutr. 2014 Jan;99(1):86-95. doi: / . Epub 2013 Nov 20.
11. Foucault AS et al. Quinoa extract enriched in 20-hydroxyecdysone affects energy homeostasis and intestinal fat absorption in mice fed a high-fat diet. Physiol Behav. 2014 Feb 15;128C:226-231. doi: /. [Epub ahead of print]
12. Gorelick-Feldman J, Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells. Cohick W, Raskin . 2010 Oct;75(10):632-7. doi: /. Epub 2010 Apr 2.
13. Cheng DM1, Kutzler LW, Boler DD, Drnevich J, Killefer J, Lila MA. Continuous infusion of 20- hydroxyecdysone increased mass of triceps brachii in C57BL/6 mice. Phytother Res. 2013 Jan;27(1):107-11. doi: /. Epub 2012 Apr 12.
14. Witard OC1, Jackman SR, Breen L, Smith K, Selby A, Tipton KD. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise. Am J Clin Nutr. 2014 Jan;99(1):86-95. doi: /. Epub 2013 Nov 20.
15. Syrov VN, Iuldasheva NKh, Égamova FR, Ismailova GI, Abdullaev ND, Khushbaktova ZA. [Estimation of the hypoglycemic effect of phytoecdysteroids]. Eksp Klin Farmakol. 2012;75(5):28-31. [Article in Russian]
16. Foucault AS1, Mathé V, Lafont R, Even P, Dioh W, Veillet S, Tomé D, Huneau JF, Hermier D, Quignard- Boulangé A. Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression. Obesity (Silver Spring). 2012 Feb;20(2):270-7. doi: /. Epub 2011 Aug 25.
17. Korkach IuP et al. [NO-dependent mechanisms of ecdysterone protective action on the heart and vessels in streptozotocin-induced diabetes mellitus in rats]. Fiziol Zh. 2007;53(3):3-8.[Article in Ukrainian]
18. Zhegn GY et al. [Preparation and dose-effect analysis of ecdysterone cream for promoting wound healing].Nan Fang Yi Ke Da Xue Xue Bao. 2008 May;28(5):828-31.[Article in Chinese]
19. Ehrhardt C1, Wessels JT, Wuttke W, Seidlová-Wuttke D. The effects of 20-hydroxyecdysone and 17β- estradiol on the skin of ovariectomized rats. menopause. 2011 Mar;18(3):323-7. doi: /gme. 0b013e3181f322e3.

Phytoecdysteroids in plants

phytoecdysteroids in plants

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone , which is secreted from the prothoracic glands . Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids . Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster , an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Recent findings in Chris Q. Doe lab have found a novel role of this hormone in regulating temporal gene transitions within neural stem cells. [1] Ecdysone and other ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps , yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties. [2] A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids.

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