According to statistics, if the vasectomy reversal is performed less than 3 years after the vasectomy , about 97 percent of men have sperm in the ejaculate, and the pregnancy rate is about 75 percent. If the vasectomy reversal is performed between 3 and 8 years after the vasectomy , the rate for sperm in the ejaculate is about 90 percent, and the pregnancy rate is about 50 percent. If the vasectomy reversal is performed more than 15 years after the vasectomy , the rate of sperm in the ejaculate is about 70 percent, and the pregnancy rate is about 30 percent.
The overall response rate (CR + PR) of % in Vidaza-treated patients without AML (% for all Vidaza randomized patients including AML) was statistically significantly higher than the response rate of 0% in the observation group (p<) ( Table 5 ). The majority of patients who achieved either CR or PR had either 2 or 3 cell line abnormalities at baseline (79%; 11/14) and had elevated bone marrow blasts or were transfusion dependent at baseline. Patients responding to Vidaza had a decrease in bone marrow blasts percentage, or an increase in platelets, hemoglobin or WBC. Greater than 90% of the responders initially demonstrated these changes by the 5 th treatment cycle. All patients who had been transfusion dependent became transfusion independent during PR or CR. The mean and median duration of clinical response of PR or better was estimated as 512 and 330 days, respectively; 75% of the responding patients were still in PR or better at completion of treatment. Response occurred in all MDS subtypes as well as in patients with adjudicated baseline diagnosis of AML.