Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.
Dianabol is not an extremely androgenic steroid, its androgenicity has been structurally reduced, but androgenic side effects are still possible. Such side effects of Dianabol use include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Most men should not have a problem with such effects, response will be the final dictator, but most will remain clear. Although the odds are in your favor, such effects are brought on by Methandrostenolone being metabolized by the 5-alpha reductase enzyme. This is the same enzyme responsible for the reduction of testosterone to dihydrotestosterone, but the overall conversion here will result in very low amounts of dihydromethandrostenolone. This tells us 5-alpha reductase inhibitors like Finasteride that are often used to combat androgenic side effects will have very little if any affect on Dianabol.
Despite its reduced androgenicity, Dianabol can promote virilization symptoms in women. Such symptoms include body hair growth, a deepening of the vocal chords and clitoral enlargement. It is possible for some women to use this steroid without virilization symptoms with extremely low doses, but the odds are not favorable. Most all women should choose anabolic steroids with less translating androgenic activity to meet their needs.
The most common side effect of topical corticosteroid use is skin atrophy. All topical steroids can induce atrophy, but higher potency steroids, occlusion, thinner skin, and older patient age increase the risk. The face, the backs of the hands, and intertriginous areas are particularly susceptible. Resolution often occurs after discontinuing use of these agents, but it may take months. Concurrent use of topical tretinoin (Retin-A) % may reduce the incidence of atrophy from chronic steroid applications. 30 Other side effects from topical steroids include permanent dermal atrophy, telangiectasia, and striae.