Some side effects associated with spinal puncture include bruising, bleeding, infections, headaches, and blood clots. Cortisone side effects may cause weight gain, water retention, hot flashes, mood swings or insomnia, and elevated blood sugar levels in people with diabetes. Epidural steroid injections can provide diagnostic and therapeutic benefits. ESIs have been endorsed by the North American Spine Society and the Agency for Healthcare Research and Quality of the Department of Health and Human Services. Discuss this procedure with your friendly and caring doctor at the Florida Spine Institute to determine whether it is the right treatment for you.